Fibrillar Collagens in Vocal Polyp and Nodule

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J Korean Soc Laryngol Phoniatr Logop > Volume 9(1); 1998 > Article

Journal of The Korean Society of Laryngology, Phoniatrics and Logopedics 1998;9(1): 17-21.

성대폴립 및 결절에서의 원섬유성 교원질 (Fibrillar Collagen)의 발현양상

손영익¹, 고영혜², 고석주¹

¹성균관대학교 의과대학 삼성서울병원 이비인후과학교실²성균관대학교 의과대학 삼성서울병원 진단병리과학교실

Fibrillar Collagens in Vocal Polyp and Nodule

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ABSTRACT

Benign vocal fold lesions such as polyps, nodules and edema are known to be caused by vocal trauma such as voice misuse and/or abuse. Even though these lesions are known to be caused by the same etiology, phonotrauma, they show widely different clinical features and different responses to voice therapy. Previous studies suggested that benign vocal fold lesions represent disturbance in the balance of the extracellular matrix(ECM) constituents of the vocal folds. Collagen is one of the major constituents of ECM. Among collagens, fibrillar collagens are most important ones for maintaining the structural integrity. On the basis of gross morphology, vocal polyps wert divided into angiomatous one and edematous one, and nodules were divided into conical one and sessile one. In these four groups, the pattern of distribution of various fibrillar collagens(type 1, 2, 3, 5) was studied by immunohistochemical staining using paraffin embedded tissues. Within each group, differences among collagen subtypes were insignificant. In edematous polyp, collagens were sparsely dispersed in lamina propria by diffuse edema. In angiomatous polyp, collagens were displaced into submucosal layer by hemorrhagic space. In nodules, collagens were stained compactly in lamina propria. Quite different distributions of fibrillar collagens between polyps and nodules are thought to suggest that vocal polyps and nodules are totally different disorders in their pathophysiology.

KEY WORDS： Vocal polyp;Vocal nodule;Fibrillar collagen;