Botulinum Toxin : Basic Science and Clincal Uses in Otolaryngology

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J Korean Soc Laryngol Phoniatr Logop > Volume 13(2); 2002 > Article

Journal of The Korean Society of Laryngology, Phoniatrics and Logopedics 2002;13(2): 164-172.

Botulinum Toxin : 기초과학과 이비인후과 영역에서의 임상적 사용

최홍식, 문인석, 김한수, 김현직

연세대학교 의과대학 이비인후과학교실, 음성언어의학연구소

Botulinum Toxin : Basic Science and Clincal Uses in Otolaryngology

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ABSTRACT

The role of botulinum toxin as a therapeutic agent is expanding rapidly in otolaryngology. Botulinum toxin is a protease that blocks the release of acetylcholine from nerve terminals. Its effects are transient and nondestructive, and largely limited to the area in which it is administered These effects are also graded according to the dose, allowing for individualized treatment of patients and disorders. Botulinum toxin has been used primarily to treat disorders of excessive or inappropriate muscle contraction. In the field of otolaryngology, these include spasmodic dysphonia, oromandibular dystonia, and blepharospasm, vocal tics and stuttering, cricopharyngeal achalasia, various tremors and tics, hemifacial spasm, temporomandibular joint disorders and a number of cosmetic applications. Botulinum toxin treatment has recently begun to show some benefit in the control of pain from migraine and tension headache. It may also prove useful in the control of autonomic dysfunction, as in Frey syndrome, sialorrhea, and rhinorrhea. In over 20 yews of use in humans, botulinum toxin has accumulated a considerable safety record, and in many cases represents relief for thousands of patients unaided by other therapy.

KEY WORDS： Botulinum toxin;Dystonia;Spasmodic dysphonia;Laryngeal disease;Oromandibular dystonia;Cricopharyngeal spasm;Blepharospasm;Facial lines;Migraine;Frey syndrome;Facial synkinesis;Hemifacial spasm;

중심 단어： 근긴장 이상;연축성 발성장애;후두질환 구강하악 근긴장이상;윤상인두 이완불능증;안검경련;안면선 편두통;Frey 증후근;안면공동운동 안명 경련;