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J Korean Soc Laryngol Phoniatr Logop > Volume 16(2); 2005 > Article
Journal of The Korean Society of Laryngology, Phoniatrics and Logopedics 2005;16(2): 129-134.
일측성 성대마비 환자에서 Artecoll을 이용한 성대주입술의 효과 및 안전성
오재원1, 이승원2, 김민범1, 윤영선1, 김관민3, 손영익1
1성균관대학교 의과대학 삼성서울병원 이비인후과학교실
2순천향대학교 의과대학 이비인후과학교실
3성균관대학교 의과대학 삼성서울병원 흉부외과학교실
The Effect of Artecoll Injection for the Patients with Unilateral Vocal Cord Paralysis
Jae-Won Oh1, Seung-Won Lee2, Min-Beom Kim1, Young-Sun Yun1, Kwan-Min Kim3, Young-Ik Son1
1Department of Otorhinolaryngology-Head and Neck Surgery, Sungkyunkwan University School of Medicine
2Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Soonchunhyang University
3Department of Thoracic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine
ABSTRACT
Background and Objectives : Artecoll(R) is an injectable soft tissue filler, which is a suspension of polymethylmethacrylate microspheres in $3.5%$ bovine collagen solution. The authors aimed to determine the clinical of Artecoll of Artecoll(R) as an injection material into the vocal fold to correct the glottal insufficiency caused by unilateral vocal cord paralysis. Materials and Methods : Forty-one consecutive patients with unilateral vocal cord paralysis received percutaneous Artecoll injections under local anesthesia. Acoustic, aerodynamic and stroboscopic analyses were prospectively provided before, 1 week and 3 months after injection. Perceptual GRBAS grading by speech language pathologists and subjective ratings of the hoarseness and aspiration by the patients were also obtained. Results : Aerodynamic parameter(maximal phonation time) were significantly improved after the injection (p<0.05). Acoustic parameters (jitter and shimmer) were improved at the 3rd month follow-up. GRBAS uading and patients own subjective scaling of hoarseness and aspiration also showed significant improvement (p<0.05). Early or delayed significant side effects were not observed. Conclusion : Vocal fold injection with Artecoll is a convenient, safe and useful method of temporarily correcting the glottal insufficiency. Further long-term follow-up studies will answer the usefulness and safety of the Artecoll injection laryngoplasty.
KEY WORDS: Vocal cord paralysis;Injections;Collagen;Polymethylmethacrylate;Treatment outcomes.;
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