Trend of Basic Research for Vocal Fold Scar

Lee, Byung-Joo

J Korean Soc Laryngol Phoniatr Logop > Volume 23(1); 2012 > Article

Journal of The Korean Society of Laryngology, Phoniatrics and Logopedics 2012;23(1): 28-32.

성대 반흔에 대한 기초연구의 최신 경향

이병주

부산대학교 의학전문대학원 이비인후과학교실

Trend of Basic Research for Vocal Fold Scar

Byung-Joo Lee

Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine

ABSTRACT

Vocal fold scar disrupts structure of lamina propria and causes significant change in vocal fold tissue biomechanics, resulting in a range of voice problems that often significantly compromise patient quality of life. Although several therapeutic management have been offered in an attempt to improve vocal fold scar, the ideal treatment has not yet been found. Recently, several tissue engineering technique for vocal fold scar using growth factors, several cells, and scaffolds have been described in tissue culture and animal models. Several growth factors such as hepatocyte growth factor, basic fibroblast growth factor, and transforming growth factor beta 3 for therapy and prevention of vocal fold scar have been studied. Cell types to regenerate vocal folds in scarring tissue have been introduced autologous or scarred vocal fold fibroblast and adult mesenchymal stem cells. Decellularized organ matrix and several hyaluronic acid materials have used as scaffolds for vocal fold scar.

KEY WORDS： Vocal fold scar;Growth factors;Stem cells;Scaffold;Animal models;

중심 단어： 성대 반흔;성장 인자;줄기세포;지지체;동물 모델;