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J Korean Soc Laryngol Phoniatr Logop > Volume 26(1); 2015 > Article
Journal of The Korean Society of Laryngology, Phoniatrics and Logopedics 2015;26(1): 58-62.
후두에 발생한 파종성 황색종 1예
박진수, 이용우, 이상혁, 진성민
성균관대학교 의과대학 강북삼성병원 이비인후과학교실
A Case of Xanthoma Disseminatum with Laryngeal Involvement
Jin Su Park, Young Woo Lee, Sang Hyuk Lee, Sung Min Jin
Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine
ABSTRACT
Xanthoma disseminatum (XD) is a benign, non-Langerhans cell histiocytosis characterized by disseminated xanthomatous lesions with face, flexures, and mucosa. Most of XD develops in mucocutaneous lesions including skin, oral cavity and pharynx, however laryngeal involvement is uncommon. While the natural course of XD is usually benign and often self-limiting, but XD develop in critical anatomical locations may result in morbidity and mortality. Localized mucous lesions in oropharynx and larynx lead to dysphagia, dyspnea and air way obstruction. The diagnosis of XD was based on clinical, histological and immunohistochemical findings. The treatment is complex and non-consensual. Local treatment with cryotherapy, radiotherapy, surgery, and carbon dioxide lasers have been attempted with various results. Systemic medication with peroxisome proliferator-activated gamma receptors, statins, fenofibrate, chlorodeoxyadenosine, cyclophosphamide, doxycycline, and cyclosporine have also been reported, but none have proven particularly successful. A 59-year-old man presented with respiratory symptoms because of laryngeal involvement of XD. We had to remove the obstructive lesion for relieving the symptoms. We experienced XD in Larynx that was rare in otorhinolaryngology. So we report this case with review of literatures.
KEY WORDS: Xanthoma disseminatum;Larynx;Non-langerhans cell histiocytosis;
중심 단어: 파종성 황색증;후두;비 랑게르한스 세포 조직구증;
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