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J Korean Soc Laryngol Phoniatr Logop > Volume 28(1); 2017 > Article
Journal of The Korean Society of Laryngology, Phoniatrics and Logopedics 2017;28(1): 32-37.
doi: https://doi.org/10.22469/jkslp.2017.28.1.32
양성자펌프억제제, 스테로이드흡입제, 보툴리늄톡신 주사를 이용한 접촉성 육아종의 치료 결과
박형민, 오나래, 백민관, 김동영, 우주현
가천대학교 의과대학 이비인후과학교실
Treatment Result of Proton Pump Inhibitor, Steroid Inhaler and Botulinum Tonxin Injection for Contact Granuloma
Hyoung Min Park, Na Rae Oh, Min Kwan Baek, Dong Young Kim, Joo Hyun Woo
Department of Otorhinolaryngology Head and Neck Surgery, School of Medicine, Gachon University, Gil Medical Center, Incheon, Korea
Correspondence  Joo Hyun Woo ,Tel: (032) 460-3765, Fax: (032) 467-9044, Email: woojh@gilhospital.com
Received: 29 March 2017; Revised: May 9, 2017   Accepted: 2 June 2017.  Published online: 30 June 2017.
Background and Objectives
This study evaluated the efficacy of combination therapy of proton pump inhibitor (PPI) and steroid inhaler (SI), with or without botulinum toxin injection (BTX) for contact granuloma. Subjects and Methods:Fourteen contact granuloma patients were enrolled in this study. Combination therapy of PPI and SI were used for the first line treatment. When combination therapy was not effective, BTX was performed as the second method. Treatment results were recorded as responsible or non-responsible. Farwell grade, size, history of voice abuse, gender, and reflux finding score (RFS) were compared between responsible group and non-responsible group.
Initial response rate was 28.6% after treatment of PPI and SI. BTX was performed on three un-responsible patients. After BTX injection, three patients had complete remission of granuloma. Final response rate was 50.0%. Un-responsible group had significantly higher RFS than responsible group.
The efficacy of PPI and SI was limited for contact granuloma in this study. Botulium toxin injection was recommended in early phase when PPI and SI did not effective for contact granuloma. Prospective studies evaluating the effects of PPI and SI are warranted.
KEY WORDS: GranulomaVocal cordsProton pump inhibitorSteroid
중심 단어: 육아종성대양성자펌프억제제스테로이드
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