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J Korean Soc Laryngol Phoniatr Logop > Volume 10(2); 1999 > Article
Journal of The Korean Society of Laryngology, Phoniatrics and Logopedics 1999;10(2): 102-118.
개에서 후두수직절반 이식 후 형태 및 기능에 대한 연구
김영찬1, 최홍식2, 정유삼2, 양해동2, 김태만2, 강성석2, 정형진2, 조성우2, 이성민2
1연세이비인후과2연세대학교 의과대학 이비인후과학교실 음성언어의학연구소
Morphological and Functional Outcomes after Vertical Hemilaryngeal Transplantation in the Canine
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ABSTRACT
In this study, the author developed a new animal model to examine morphological changes and functional recoveries after vertical hemilaryngeal transplantation in the canine. Seven vertical hemilaryngeal transplantations were carried out in the canine. After preparing the host dog removing right sided hemilarynx, hemilarynx of the donor dog was transplanted by hooking up the arteries, veins, nerves and hypopharyngeal mucosa. Especially, recurrent laryngeal nerve was anastomosed at the branch level(anterior and posterior) respectively. After 7 days, for the first evaluation of the transplantation, four out of seven dogs were considered successful. Three dogs survived more than one month, which is the critical period to evaluate the functional recovery after transplantations. After EMG examination, two dogs(#3, #5 dog) showed some functional recoveries. The five-transplanted hemilarynges were sectioned at the arytenoid cartilage region to examine the morphological changes. The results showed that the transplanted hemilarynx appeared normal as control in #5 dog. In addition, #2 dog showed fairly good condition even though died from asphyxia after 9 days out of transplantation. The other. three dogs(#3, #6, #7) showed various levels of atrophy and disappearance of the muscles and cartilages in their larynges. It can be suggested that this model could contribute an advance to preparing human laryngeal transplantation in the future.
KEY WORDS: Laryngeal transplantation;Vertical hemilaryngeal transplantation;Animal model;
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