Present Status and Prospect of Researches on Laryngopharyngeal Reflux

Choi, Seung-Ho

J Korean Soc Laryngol Phoniatr Logop > Volume 18(2); 2007 > Article

Journal of The Korean Society of Laryngology, Phoniatrics and Logopedics 2007;18(2): 113-117.

인후두역류 관련 연구의 현황 및 전망

최승호

울산대학교 의과대학 서울아산병원 이비인후과학교실

Present Status and Prospect of Researches on Laryngopharyngeal Reflux

Seung-Ho Choi

Department of Otolaryngology, Asan Medicine Center, University of Ulsan College of Medicine

ABSTRACT

Although the prevalence of laryngopharyngeal reflux (LPR) is presumed to be very high, basic researches on LPR have not been active so far. This is a review of present status and prospect of researches on LPR to help readers' understanding of current trend on LPR research. In vitro and in vivo researches on acid/pepsin, intercellular junctions, bile juice, carbonic anhydrase, cytokines, and Helicobacter pylori were discussed. Considering that quality of life is getting more important in accordance with longer life span and that a fair proportion of LPR patients do not respond to conventional therapy, researches on pathogenesis and pathophysiology of treatment measures are necessary and it is anticipated for more and more researchers to concern themselves in basic research on LPR in the future.

KEY WORDS： Laryngopharyngeal reflux;Research;Animal experimentation;

중심 단어： 인후두역류;기초연구;동물실험;