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J Korean Soc Laryngol Phoniatr Logop > Volume 20(2); 2009 > Article
Journal of The Korean Society of Laryngology, Phoniatrics and Logopedics 2009;20(2): 136-140.
재발성 호흡기 유두종증의 병변내 시도포비어 치료
송형용, 한명월, 최승호, 김상윤, 남순열
울산대학교 의과대학 서울아산병원 이비인후과학교실
Intralesional Cidofovir Therapy for Recurrent Repiratory Papillomatosis
Hyoung-Yong Song, Myung-Woul Han, Seung-Ho Choi, Sang-Yoon Kim, Soon-Yuhl Nam
Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine
Background and Objectives:
Recurrent respiratory papillomatosis (RRP) is difficult to treat because of its tendency to recur and spread throughout the aerodigestive tract. We aimed to estimate the effect of intralesional injections of cidofovir in patients with RRP.
Materials and Method:
Within the period from January 2003 to July 2007, 13 patients aged 2 to 61 years were treated with intralesional injections of cidofovir combined with surgical excision of RRP. Cidofovir was injected intralesionaly at a concentration of 5 mg/cc after complete removal of the papilloma with $CO_2$ laser or microdebrider. We evaluated the effect of intralesional cidofovir therapy by comparing pre-treatment mean interval of recurrence with post-treatment interval of recurrence.
Of 13 patients, two patients showed complete response during follow up period and four patients showed partial response. Seven patients did not respond to cidofovir at all. Mean pre-treatment mean interval of recurrence was 9 months and mean post-treatment interval of recurrence was 13.1 months (p=0.039). There was a statistical significance between the injected dose of cidofovir and post-treatment interval of recurrence (p=0.009). There were no local or systemic side effects caused by cidofovir. Conculsion : Intralesional injection of cidofovir seems to have a potential of a safe and effective adjuvant therapy of RRP. There was a positive correlation between the injected dose of cidofovir and patient clinical outcomes so that administration of higher doses and more frequency of injections should be needed to reduce recurrence. Further study regarding injection therapy regimen for RRP is required.
KEY WORDS: Cidofovir;Papillomatosis;
중심 단어: 시도포비어;유두종증;
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