| Home | E-Submission | Sitemap | Editorial Office |  
top_img
J Korean Soc Laryngol Phoniatr Logop > Volume 23(1); 2012 > Article
Journal of The Korean Society of Laryngology, Phoniatrics and Logopedics 2012;23(1): 28-32.
성대 반흔에 대한 기초연구의 최신 경향
이병주
부산대학교 의학전문대학원 이비인후과학교실
Trend of Basic Research for Vocal Fold Scar
Byung-Joo Lee
Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine
ABSTRACT
Vocal fold scar disrupts structure of lamina propria and causes significant change in vocal fold tissue biomechanics, resulting in a range of voice problems that often significantly compromise patient quality of life. Although several therapeutic management have been offered in an attempt to improve vocal fold scar, the ideal treatment has not yet been found. Recently, several tissue engineering technique for vocal fold scar using growth factors, several cells, and scaffolds have been described in tissue culture and animal models. Several growth factors such as hepatocyte growth factor, basic fibroblast growth factor, and transforming growth factor beta 3 for therapy and prevention of vocal fold scar have been studied. Cell types to regenerate vocal folds in scarring tissue have been introduced autologous or scarred vocal fold fibroblast and adult mesenchymal stem cells. Decellularized organ matrix and several hyaluronic acid materials have used as scaffolds for vocal fold scar.
KEY WORDS: Vocal fold scar;Growth factors;Stem cells;Scaffold;Animal models;
중심 단어: 성대 반흔;성장 인자;줄기세포;지지체;동물 모델;
TOOLS
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
CrossRef TDM  CrossRef TDM
  E-Mail
  Print
METRICS
529
View
12
Download
Related article
Current Researches on Vocal Fold Aging  2014 June;25(1)
Editorial Office
Journal of The Korean Society of Laryngology, Phoniatrics and Logopedics, Gachon University School of Medicine
Namdong-daero 774 beon-gil, Namdong-gu, Incheon, 21565, South Korea
TEL: +82-32-460-3765   FAX: +82-32-467-9044   E-mail: woojh@gilhospital.com
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © Journal of The Korean Society of Laryngology, Phoniatrics and Logopedics.                 Developed in M2PI