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Effectiveness of proton pump inhibitor for the treatment of contact granuloma
DongHwan Kim, Keon Ho Kim, Seon Min Jung, Chang myeon Song, Yong Bae Ji, Kyung Tae
Hanyang univ. hospital, Seoul, Korea
Correspondence  DongHwan Kim ,Tel: +82 2)2290-8588, Fax: +82 2)2293-3335, Email: eastsun89@nate.com
Received: 31 October 2017;  Accepted: 26 November 2017.  Published online: 26 November 2017.
Background and Objectives:
Contact granuloma is granulation tissue that occurs mainly in the vocal process of arytenoid cartilage. Among several etiological factors, gastric acid reflux is known to be an important cause. The aim of this study was to evaluate clinical characteristics of contact granuloma and analyze the effectiveness of proton pump inhibitor in the treatment of contact granuloma. Materials and
We retrospectively reviewed the medical records of 40 patients who were treated with proton pump inhibitor (PPI) for contact granuloma from January 2011 to December 2015. Reflux finding score (RFS), reflux symptom index (RSI) and size of granuloma were evaluated before and after treatment serially to assess the effectiveness of proton pump inhibitor.
Of 40 patients, 25 patients (62.5%) and 10 patients (25%) showed complete and partial remission of granuloma, respectively. Five patients showed stable disease. The mean times of partial and complete remission were 2.08 ± 2.23 months and 4.60 ± 2.77 months, respectively and mean duration of PPI treatment was 6.8 ± 5.2 months.
Proton pump inhibitors is effective in the treatment of contact granuloma.
KEY WORDS: Contact granuloma; Proton pump inhibitor; Laryngopharyngeal reflux; Gastroesophageal reflux
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