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J Korean Soc Laryngol Phoniatr Logop > Volume 31(2); 2020 > Article
Journal of The Korean Society of Laryngology, Phoniatrics and Logopedics 2020;31(2): 66-70.
doi: https://doi.org/10.22469/jkslp.2020.31.2.66
노화 쥐 성대의 조직학적 분석
신성찬1,2 , 김지민2 , 권현근1,2 , 천용일1,2 , 이병주1,2
1부산대학교 의과대학 이비인후과학교실
2부산대학교병원 의생명연구원
Histologic Analysis of Vocal Folds in Aging Rats
Sung-Chan Shin1,2 , Ji Min Kim2 , Hyun-Keun Kwon1,2 , Yong-Il Cheon1,2 , Byung-Joo Lee1,2
1Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine, Busan, Korea
2Biomedical Research Institute, Pusan National University Hospital, Busan, Korea
Correspondence  Byung-Joo Lee ,Tel: +82-51-240-7675, Fax: +82-51-240-2162, Email: voiceleebj@gmail.com
Received: 3 November 2020; Revised: November 19, 2020   Accepted: 3 December 2020.  Published online: 30 December 2020.
ABSTRACT
Background and Objectives Presbyphonia is characterized by hoarse, breathy, weak vocal intensity. Extracellular matrix (ECM) in lamina propria (LP) of the vocal folds play an important role in voice production, and change of ECM according to the aging leads to the presbyphonia. The aim of this study was to investigate the histologic analysis of aging vocal fold of rat. Materials and Method Six and twenty two months old Sprague-Dawley rats (n=8, each group) were used and classified into young (six months old rats) and old (twenty two months old rats) group. Histologic analysis and immunohistochemical staining for ECM of LP were performed. Results Overall cellular density was significantly decreased in old rat group. Elastin fibers of LP were significantly decreased in old rat group. Type I collagen was significantly increased in old rat group. Type III collagen did not show significant difference. Hyaluronic acids did not show significant difference in Alcian blue staining and immunohistochemical staining. Conclusion Decreased general cellular density and elastin fiber and increased type I collagen were observed in the LP of vocal folds of aging rats. These ECM changes might to contribute the aging voice.
KEY WORDS: Aging; Vocal folds; Extracellular matrix; Histology
중심 단어: 노화, 성대, 세포외 기질, 조직
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