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J Korean Soc Laryngol Phoniatr Logop > Volume 28(2); 2017 > Article
Journal of The Korean Society of Laryngology, Phoniatrics and Logopedics 2017;28(2): 123-127.
doi: https://doi.org/10.22469/jkslp.2017.28.2.123
접촉성 육아종에서 양성자 펌프 억제제의 치료 효과
김동환, 김건호, 정선민, 송창면, 지용배, 태 경
한양대학교 의과대학 이비인후-두경부외과학교실
Effectiveness of Proton Pump Inhibitor in the Treatment of Contact Granuloma
Dong Hwan Kim, Keon Ho Kim, Seon Min Jung, Chang Myeon Song, Yong Bae Ji, Kyung Tae
Department of Otorhinolaryngology-Head and Neck Surgery, Hanyang University College of Medicine, Seoul, Korea
Correspondence  Kyung Tae ,Tel: (02) 2290-8585, Fax: (02) 2293-3335, Email: kytae@hanyang.ac.kr
Received: 31 October 2017; Revised: November 12, 2017   Accepted: 13 November 2017.  Published online: 31 December 2017.
Background and Objectives
Contact granuloma is granulation tissue that occurs mainly in the vocal process of arytenoid cartilage. Among several etiological factors, gastric acid reflux is known to be an important cause. The aim of this study was to evaluate clinical characteristics of contact granuloma and analyze the effectiveness of proton pump inhibitor in the treatment of contact granuloma.
Materials and Methods
We retrospectively reviewed the medical records of 40 patients who were treated with proton pump inhibitor (PPI) for contact granuloma from January 2011 to December 2015. Reflux finding score (RFS), reflux symptom index (RSI) and size of granuloma were evaluated before and after treatment serially to assess the effectiveness of proton pump inhibitor.
Of 40 patients, 25 patients (62.5%) and 10 patients (25%) showed improvement and partial improvement of granuloma, respectively. Five patients showed no response. The mean times of partial improvement and improvement were 2.08±2.23 months and 4.60±2.77 months, respectively and mean duration of PPI treatment was 6.8±5.2 months.
Proton pump inhibitors is effective in the treatment of contact granuloma.
KEY WORDS: Contact granulomaProton pump inhibitorLaryngopharyngeal refluxGastroesophageal reflux
중심 단어: 접촉성 육아종양성자 펌프 억제제인후두 역류위식도 역류
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